[Skip to Content]
[Skip to Content Landing]
January 1988

Striatal Syndrome Following Hyponatremia and Its Rapid CorrectionA Manifestation of Extrapontine Myelinolysis Confirmed by Magnetic Resonance Imaging

Author Affiliations

From the Department of Neurology, Mount Sinai School of Medicine, City University of New York, and the Neurology Service, Mount Sinai Hospital, New York.

Arch Neurol. 1988;45(1):112-114. doi:10.1001/archneur.1988.00520250122033

• Several pathologic reports have indicated the occurrence of extrapontine sites of myelinosis associated with electrolyte disturbance and its rapid correction. Clinical evidence of the presence of such lesions, however, have rarely been described. We report a case of a 50-year-old man who following rapid correction of electrolyte imbalance developed a profound striatal syndrome. The clinical manifestations, the course of his illness as well as response to therapy, confirmation of lesion sites by magnetic resonance imaging (MRI), and abnormalities on visually evoked potentials are described in detail.