• A rare case of homozygous protein C deficiency occurred in a newborn. The patient presented with purpura fulminans in the first few hours after birth and showed multiple hemorrhagic lesions on computed tomography of the brain at 5 days of age. Neurologic symptoms developed at two weeks and the patient died at 37 weeks. His protein C level was less than 5%. Autopsy revealed thrombosis of the dural sinuses, multiple cortical infarcts, intraparenchymal hemorrhages, and hydrocephalus. The pathologic findings are correlated with the neurologic deficits and previously documented cases are reviewed.
Tarras S, Gadia C, Meister L, Roldan E, Gregorios JB. Homozygous Protein C Deficiency in a NewbornClinicopathologic Correlation. Arch Neurol. 1988;45(2):214–216. doi:10.1001/archneur.1988.00520260102029