March 1988

Early Alzheimer's DiseaseDiagnostic Considerations

Author Affiliations

From the Departments of Neurology and Neurological Surgery (Neurology) (Dr Morris) and Pathology (Division of Neuropathology) (Dr Fulling), and the Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis.

Arch Neurol. 1988;45(3):345-349. doi:10.1001/archneur.1988.00520270127033

• An 82-year-old cognitively healthy man was assessed longitudinally until very mild senile dementia of the Alzheimer type was diagnosed by clinical research criteria and documented by psychometric testing at age 85 years. Four months after diagnosis, Alzheimer's disease was confirmed neuropathologically. The diagnostic difficulties involved in distinguishing early senile dementia of the Alzheimer type-Alzheimer's disease from normal aging are examined and clinical and pathologic features useful for their discrimination are discussed.