• Patients with computed tomographic scan-verified unilateral lesions in the basal ganglia or thalamus were examined for the presence of poststroke mood disorders. Patients with left-sided basal ganglia lesions (mainly in the head of the caudate nucleus) showed a significantly higher frequency and severity of depression, as compared with patients with right-sided basal ganglia or thalamic (leftor right-sided) lesions. Results suggest that damage to biogenic amine pathways and/or frontocaudate projections may play an important role in the modulation of mood.
Starkstein SE, Robinson RG, Berthier ML, Parikh RM, Price TR. Differential Mood Changes Following Basal Ganglia vs Thalamic Lesions. Arch Neurol. 1988;45(7):725–730. doi:10.1001/archneur.1988.00520310031013