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August 1988

Impaired Visual Contrast Sensitivity in Epileptic Patients Treated With Carbamazepine

Author Affiliations

From the Departments of Neurology (Drs Tomson and Levi) and Clinical Neurophysiology (Dr Nilsson), Karolinska Institute, Södersjukhuset, Stockholm, and the Department of Clinical Pharmacology, Karolinska Institute, Huddinge (Sweden) University Hospital (Dr Tomson).

Arch Neurol. 1988;45(8):897-900. doi:10.1001/archneur.1988.00520320095021

• Critical flicker fusion frequencies and visual contrast sensitivity were determined in 27 adult epileptic patients receiving carbamazepine monotherapy and in 24 healthy, drug-free control subjects. Flicker fusion thresholds were the same in patients and control subjects, whereas the contrast sensitivity was significantly reduced in the patient group at all spatial frequencies. There was a significant negative correlation between the plasma concentration of carbamazepine and the contrast sensitivity at 11.4 and 22.8 cycles per degree, indicating that the reduced contrast sensitivity was due to the drug therapy.