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Conventional experience suggests that high-grade gliomas do not respond to chemotherapy. However, Cairncross and Macdonald have found anaplastic oligodendroglioma to be chemoresponsive. Their results are impressive, but their series is small. While questions remain about subtypes, dose, and the best chemotherapeutic combination, it is already clear that at least some anaplastic oligodendrogliomas are chemosensitive.—
Hachinski V. Are Anaplastic Oligodendrogliomas Chemosensitive?. Arch Neurol. 1991;48(2):227. doi:10.1001/archneur.1991.00530140125028