To the Editor.
—In an imaging study of Alzheimer's disease and normal aging, Leys et al,1 using our rating scale,2 found no difference in magnetic resonance imaging white matter hyperintensities between the two groups, and only a trend toward increased periventricular hyperintensity in patients with Alzheimer's disease. This is in contrast to our initial observation of a hyperintense "halo" in six of 12 cases of Alzheimer's disease.2 We would like to emphasize, however, that a part of us (F.F., R.S., H.O.) could not replicate this finding in a subsequent study performed under similar conditions. There still remains a trend toward more signal abnormalities in Alzheimer's disease, however. The Table summarizes the current data from subjects without cerebrovascular risk factors in this ongoing project.3A disproportionately higher number of patients with more marked ventricular enlargement in our first study appears to be the likeliest explanation for these
Fazekas F, Schmidt R, Offenbacher H, Chawluk JB, Alavi A. Magnetic Resonance Imaging Hyperintensities in Alzheimer's Disease. Arch Neurol. 1991;48(5):468–469. doi:10.1001/archneur.1991.00530170028012