March 1992

Hypersexuality Following Septal Injury

Author Affiliations

From the Departments of Neurology (Drs Gorman and Cummings) and Psychiatry and Biobehavioral Sciences (Dr Cummings), UCLA School of Medicine, and the Behavioral Neuroscience Section, Psychiatry Service, West Los Angeles Veterans Affairs Medical Center (Drs Gorman and Cummings), Los Angeles, Calif.

Arch Neurol. 1992;49(3):308-310. doi:10.1001/archneur.1992.00530270128029

• Hypersexuality is an uncommon consequence of brain injury. We report two cases of markedly increased sexual activity following septal damage sustained in the course of placement of ventriculoperitoneal shunts. These two cases, observations in animal experiments, and descriptions of altered behavior in humans with localized brain dysfunction indicate that a circuit involving the septal nuclei has an important role in the mediation of sexual behavior.