• To study the risk factors for septic encephalopathy, we reviewed a consecutive series of 84 patients with septic syndrome and multiple-organ failure. Septic encephalopathy developed in 14 of these patients. Univariate analysis revealed that severe hypotension was significantly associated with the development of septic encephalopathy. In stepwise multiple logistic regression analysis, no other variable made a significant contribution in the presence of severe cardiovascular failure. Septic encephalopathy may be related to ischemic damage rather than to metabolic causes.
Wijdicks EFM, Stevens M. The Role of Hypotension in Septic Encephalopathy Following Surgical Procedures. Arch Neurol. 1992;49(6):653-656. doi:10.1001/archneur.1992.00530300093015