January 1997

Autoimmune Neurologic Disease

Author Affiliations

Rochester, NY


by Michael P. Pender and Pamela A. McCombe, 377 pp, $100, New York, NY, Cambridge University Press, 1995.

Arch Neurol. 1997;54(1):19. doi:10.1001/archneur.1997.00550130011007

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The authors of this book have attempted to "provide a comprehensive overview of the immunological aspects of autoimmune neurological disease." Beginning with chapters on antigen recognition, self-nonself discrimination, and general aspects of neuroimmunology, the authors introduce the principal components of the immune system, effector and regulatory functions, as well as the cells and structures (eg, the blood-brain barrier) of the central and peripheral nervous system that are involved in the autoimmune processes to be discussed.

Experimental allergic encephalomyelitis (EAE) is then introduced as a model for multiple sclerosis and autoimmune neurological diseases in general. Methods of induction, pathogenesis, and pathological and immunological findings are discussed in detail. One shortcoming here is the limited discussion of cytokines that have been the focus of many recent advances. This is particularly apparent in the section on therapeutic interventions for EAE, where T-cell vaccinations and anti—T-cell receptor treatments are discussed

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