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April 1997

Alzheimer Disease and Frontotemporal Dementia

Author Affiliations

Alzheimer's Disease Unit S. Cuore Fatebenefratelli Hospital Via Pilastroni 4 25123 Brescia, Italy

Arch Neurol. 1997;54(4):350. doi:10.1001/archneur.1997.00550160005001

In a recent article Levy and colleagues1 reported the preliminary results of a study aimed to investigate behavioral difference between Alzheimer disease (AD) and frontotemporal dementia (FTD) by using the Neuropsychiatric Inventory (NPI) scale, a standardized instrument that allows the assessment of several behavioral disturbances occurring in dementing illnesses. They found that disinhibition, apathy, aberrant motor behavior, and euphoria were significantly more elevated in patients with FTD, and conclude that the NPI reliably differentiates degenerative syndromes with anterior or posterior cerebral involvement and helps to characterize the behavioral syndromes of FTD and AD.1

In this investigation we used the Italian version of the NPI2 to assess behavioral disturbances in 100 patients with probable AD and 21 with FTD. Patients with FTD underwent technetium Tc 99m single photon emission computed tomography as a part of their diagnostic assessment.

The mean (±SD) composite subscale scores (frequency × severity) in

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