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April 1997

Traditional Risk Factors for Stroke in the Young-Reply

Author Affiliations

Departments of Neurology and Epidemiology and Preventive Medicine University of Maryland at Baltimore 655 W Baltimore St Baltimore, MD 21201-1559

Arch Neurol. 1997;54(4):352. doi:10.1001/archneur.1997.00550160007005

In reply  We are pleased to respond to the letter of Marini and Carolei who have performed pioneering work on the epidemiology of stroke in young adults.1 However, we take issue with several points in their letter. First, it would indeed have been informative to have included a wider range of potential risk factors for stroke in our analysis. Regrettably, the Behavioral Risk Factor Survey, which was the source of the controls for our study, was limited in its scope; we included in our article all available putative risk factors for stroke.Second, they state that the odds ratio for diabetes mellitus was higher than expected and suggests that our study may have suffered from biased sampling of cases. This is a surprising suggestion since a strength of our study was that our cases were representative (they were virtually all hospitalized cases in a defined geographic region) and our

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