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Article
July 1997

Role of Antiribosomal P Protein Antibodies in the Diagnosis of Lupus Isolated to the Central Nervous System

Author Affiliations

From the Department of Neurology, University of California, Davis.

Arch Neurol. 1997;54(7):862-864. doi:10.1001/archneur.1997.00550190052014
Abstract

Background:  When lupus presents with isolated central nervous system findings, the usual serologic markers are often absent and diagnostic difficulty with a delay in treatment is common.

Objective:  To report the usefulness of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system when results of tests for anti—double-stranded DNA antibodies are negative.

Design:  Case report.

Setting:  University medical center.

Patient:  The patient was evaluated and treated on referral and followed up for 1 year.

Results:  We describe a patient with acute onset of psychosis followed by coma and focal clonic movements with undetectable DNA antibodies. Serum antiribosomal P protein antibody levels were elevated. Steroid therapy was followed by marked clinical improvement and a decrease in antibody titer.

Conclusion:  Antiribosomal P protein antibodies provide an important confirmatory test for the diagnosis of lupus isolated to the central nervous system when results of tests for anti—double-stranded DNA antibodies are negative.

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