When lupus presents with isolated central nervous system findings, the usual serologic markers are often absent and diagnostic difficulty with a delay in treatment is common.
To report the usefulness of antiribosomal P protein antibodies in the diagnosis of lupus isolated to the central nervous system when results of tests for anti—double-stranded DNA antibodies are negative.
University medical center.
The patient was evaluated and treated on referral and followed up for 1 year.
We describe a patient with acute onset of psychosis followed by coma and focal clonic movements with undetectable DNA antibodies. Serum antiribosomal P protein antibody levels were elevated. Steroid therapy was followed by marked clinical improvement and a decrease in antibody titer.
Antiribosomal P protein antibodies provide an important confirmatory test for the diagnosis of lupus isolated to the central nervous system when results of tests for anti—double-stranded DNA antibodies are negative.
Agius MA, Chan JW, Chung S, Lee E. Role of Antiribosomal P Protein Antibodies in the Diagnosis of Lupus Isolated to the Central Nervous System. Arch Neurol. 1997;54(7):862-864. doi:10.1001/archneur.1997.00550190052014