Intravenous recombinant tissue-type plasminogen activator administered within 3 hours of symptom onset followed by heparin had a significant beneficial effect in 10 of 12 patients with vertebrobasilar ischemic stroke. Grond et alArticle provide encouraging results with this acute, combined form of therapy. An editorial by CaplanArticle and a neurological review by AdamsArticle provide essential perspectives on this study.
This Month in The Archives of Neurology. Arch Neurol. 1998;55(4):445-446. doi:10.1001/archneur.55.4.445