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Letters to the Editor
July 1998

Serious Methodological Failures Concerning Presence of HSV DNA in Surgical Tissue From Human Epileptic Seizure Foci Detected by PCR

Arch Neurol. 1998;55(7):1031-1032. doi:

As both a newly appointed member of the editorial board of the ARCHIVES and as a neurovirologist, I read the recent article by Sanders and colleagues1 with great interest. I was extremely surprised to see the authors' conclusion that, "There was a statistically significant difference in the frequency of HSV [herpes simplex virus]–positive surgical specimens from monofocal seizure epicenters compared with nonepilepsy control specimens." I had previously reviewed an earlier version of this article, submitted to another neurological journal, in which the authors had reached exactly the opposite conclusion, namely, that, "The frequency distribution of HSV in epilepsy cases and controls was not significantly different." Naturally, I was intrigued to discover what had resulted in such a dramatic reversal in the study results.

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