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Letters to the Editor
July 1998

Serious Methodological Failures Concerning Presence of HSV DNA in Surgical Tissue From Human Epileptic Seizure Foci Detected by PCR—Reply

Arch Neurol. 1998;55(7):1032. doi:

In reply

Thank you for the opportunity to respond to Tyler's concerns regarding the results reported in our study.1 We stand by our article for the following reasons: (1) Changes between the published article and the first submission to the Journal of the Neurological Sciences were made in response to reviewers' concerns regarding controls; (2) we have always been conservative in the interpretation of data, and the change to a significant difference because of controls used for comparison did not alter our discussion of relevance to etiopathogenesis of epilepsy.

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