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September 1998

New Neuropathological Criteria for Alzheimer Disease

Arch Neurol. 1998;55(9):1174-1176. doi:10-1001/pubs.Arch Neurol.-ISSN-0003-9942-55-9-ned7745

ALZHEIMER DESCRIBED neurofibrillary tangles (NFTs) and senile plaques in the brain of a patient with dementia in 1907.1 These 2 neuropathological hallmarks have been the cornerstone of neuropathological diagnosis ever since. However, since a few of these lesions are detected in most individuals older than 65 years by neuropathological examination, it has been controversial which lesions constitute normal aging and which actually portend a clinical dementia. The National Institute on Aging (NIA) has convened several workshops since the early 1980s to create a common definition of the neuropathological diagnosis of Alzheimer disease (AD). This has been an iterative process, and recently new recommendations have been proposed.

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