ALZHEIMER DESCRIBED neurofibrillary tangles (NFTs) and senile plaques in the brain of a patient with dementia in 1907.1 These 2 neuropathological hallmarks have been the cornerstone of neuropathological diagnosis ever since. However, since a few of these lesions are detected in most individuals older than 65 years by neuropathological examination, it has been controversial which lesions constitute normal aging and which actually portend a clinical dementia. The National Institute on Aging (NIA) has convened several workshops since the early 1980s to create a common definition of the neuropathological diagnosis of Alzheimer disease (AD). This has been an iterative process, and recently new recommendations have been proposed.
Hyman BT. New Neuropathological Criteria for Alzheimer Disease. Arch Neurol. 1998;55(9):1174-1176. doi:10-1001/pubs.Arch Neurol.-ISSN-0003-9942-55-9-ned7745