Embryological studies have shed light on the common origin of the nervous system and skin, both derived from ectoderm, and clinicians have delineated these associations most notably in disorders termed neurocutaneous syndromes.1 This essay traces the historical threads that were ultimately woven together into the concept of tuberous sclerosis as a neurocutaneous disorder. These citations focus on clinical and patient descriptions from the 19th and early 20th centuries.
Morse RP. Tuberous Sclerosis. Arch Neurol. 1998;55(9):1257-1258. doi:10-1001/pubs.Arch Neurol.-ISSN-0003-9942-55-9-nhn7306