Celiac disease afflicts the small intestine and results in a permanent intolerance to gluten. It has a high prevalence in Europe and its manifestations often go beyond the scope of gastrointestinal ailments. The association with neurologic disorders have long been recognized, and is increasingly being explored as forme frustes of the disorder are being encountered.
This new multi-authored textbook provides an unprecedented comprehensive look at the neurologic manifestations of celiac disease. The book is made up of 9 parts with 41 chapters and 25 addenda. It is structurally well written. The first part deals with the epidemiology of celiac disease in Europe and familiarizes the reader with both the gastrointestinal and other systemic manifestations of celiac disease. An interesting hypothesis is raised regarding the parallel evolution of the disease in Europe with the change from a nomadic to an agricultural society. Part 2 then follows with discussions of the immunocytopathologic basis of celiac disease. While markers are present and mechanisms for the gastrointestinal manifestations are more familiar, the precise pathophysiological relationship between the neurologic manifestations remain unknown and interesting theories are presented.
Epilepsy and Other Neurological Disorders in Coeliac Disease. Arch Neurol. 1998;55(12):1586–1587. doi: