The neurological community can make a major contribution to pure neuroscience through the unraveling of neurologic disease processes. Those of us privileged to work on the neurodegenerative diseases can only marvel at the molecular biochemical advances of the last 10 years and fully expect to witness an exponential growth of knowledge, which will lead to effective therapeutics early in the new millennium. The impaired synaptic function accompanying these degenerations must also be explicable in molecular terms, although the answer has so far proved elusive. The solution, however, may provide a fundamental neurobiological insight, particularly with respect to synaptic plasticity and memory, the 2 processes that underpin the science of the mind.
Masters CL, Beyreuther K. Genomic Neurology. Arch Neurol. 2000;57(1):53. doi:10.1001/archneur.57.1.53