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History of Neurology: Seminal Citations
April 2000

Manganese Intoxication

Author Affiliations

From the Department of Neurology, College of Medicine, the Catholic University of Korea, Seoul.



Arch Neurol. 2000;57(4):597-599. doi:10.1001/archneur.57.4.597

Manganese plays an important role as a cofactor in many enzymatic reactions in humans but in excess amounts can cause irreversible nervous system damage.1,2 Although manganism is a rare condition, it can be the cause of complex nervous system symptoms, especially in the setting of environmental exposure.3,4 Specifically, manganese is a well-known cause of dystonic parkinsonism.5 This article highlights several historical descriptions of the clinical manifestations, pathological changes, and attempted therapeutic intervention in manganese intoxication.

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