[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.204.247.205. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Images in Neurology
April 2000

Mixed Gangliocytoma/Pituitary Adenoma

Arch Neurol. 2000;57(4):587-588. doi:10.1001/archneur.57.4.587

A 60-YEAR-OLD woman presented with a 10-year history of gradual enlargement of her hands and feet and progressive acromegalic changes of her face (Figure 1). Six months prior to presentation, she suffered from persistent frontal headaches. She had neither visual field defects nor papilledema. Growth hormone (GH) serum concentrations were increased (31.6 mU/L; normal, <10 mU/L). Serum levels of the other pituitary hormones were normal. Neuroimaging showed a large intrasellar tumor (Figure 2), which was almost completely removed via a transsphenoidal approach. The postoperative course was uneventful. Findings from neuropathological evaluation revealed a mixture of 2 different tumor tissues: a GH-producing adenoma and a benign ganglion cell tumor with dysplastic and occasionally binucleated ganglion cells in a neuropil-like matrix (Figure 3). The histological diagnosis was mixed gangliocytoma/GH-producing adenoma.

First Page Preview View Large
First page PDF preview
First page PDF preview
×