THE STUDY of multiple sclerosis (MS) has been one of the more active and rewarding areas of neurological research in the last quarter of the 20th century. Viewed as the pathological consequence of a partially dysregulated immune response turned against certain myelin components, MS has recently joined the growing forefront of neurological illnesses for which disease-modifying treatments are now available. Yet, the continued advancement of better and more effective therapies relies on a better understanding of the pathological basis of MS, especially in relation to its associated neurological consequences.
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