I welcome Dr Hariz's comments and thank him for his kind compliments of our work. I will briefly respond to some of the points that he makes, with which, in general, I do not take strong issue.
Dr Hariz states that a "surgical procedure is much more limited in its application." This depends largely on the enthusiasm of patients and physicians. In a time when "educated" patients (through the Internet and otherwise) commonly express considerable concern over the toxic effects of drugs used to treat PD, particularly levodopa, it is not uncommon to see patients in consultation who request surgery rather than the initiation of more appropriate medical therapy. This is all the more reason that the efficacy of available surgical treatments be established carefully, including comparison with the best available medical treatment.
Lang AE. In reply. Arch Neurol. 2001;58(2):315-316. doi: