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Book Review
March 2001

Cholinesterases and Cholinesterase Inhibitors

Arch Neurol. 2001;58(3):516. doi:10.1001/archneur.58.3.516

edited by Ezio Giacobini, 270 pp, with 69 illus, $125, ISBN 1-85317-910-8, London, England, Martin Dunitz Ltd, 2000.

This 270-page book, divided into 15 chapters, covers the genetic, biochemical, pharmacologic, anatomical, and clinical applications of both acetylcholinesterase and butyrylcholinesterase and their inhibitors. Overall, the book is well written by notable individuals in this scientific field. Furthermore, as most chapters are written by different individuals, the superb job of editing brings a continuous line of thought with little in the way of redundant information. Although clearly a scientific book, it reads like a well-written detective story. The sequencing of the chapters is excellent, beginning with the history of the cholinesterases, traveling through the pharmacology, genetics, and anatomy of these compounds, and ending with clinical applications, including their use in myasthenia gravis.

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