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Letters to the Editor
May 2001

Acute Orthostatic Hypotension When Starting Dopamine Agonist Therapy in Parkinson Disease: The Role of Domperidone Therapy

Arch Neurol. 2001;58(5):835. doi:

I read with interest the article by Kujawa et al1 regarding acute orthostatic hypotension on the initiation of dopamine agonist therapy in Parkinson disease. In this study, approximately 30% of patients met the criteria for orthostatic hypotension, and 30% of these were symptomatic from this complication. As the authors indicate, orthostatic hypotension is widely recognized, particularly on the initiation of dopamine agonist therapy. Indeed, a small proportion of patients experience quite significant difficulties with this adverse effect, and it is a common experience in movement disorders clinics to see patients who have previously discontinued treatment with several dopamine agonists very early because of symptomatic orthostatic hypotension.

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