We are intrigued by the apparent negative association of 3-hydroxy-3-methylglutaryl coenzyme A inhibitor (statin) use and the presence of Alzheimer disease (AD),1 particularly since we have observed in very old patients that those with autopsy-documented AD had significantly higher levels of total and low-density lipoprotein (LDL) cholesterol than those with non-AD dementias.2,3 However, several aspects of Wolozin and colleagues' design and data presentation cloud their results.
Lesser GT, Libow LS. Statin–Alzheimer Disease Association Not Yet Proven. Arch Neurol. 2001;58(6):1022-1023. doi: