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Letters to the Editor
July 2001

In reply

Arch Neurol. 2001;58(7):1168-1169. doi:

I thank Dr Peltola and colleagues for their particular attention to my article on epilepsy and the immune system.1 They had demonstrated earlier that the cerebrospinal concentration of the cytokine IL-6 may increase after tonic-clonic seizures and suggested that the seizures activated the cytokine network.2 This information is in agreement with other recently published results,3,4 not only for human epilepsies but also for animals with experimentally induced seizures. DeSimoni et al3 observed that spontaneously recurring seizures in rats involve the activation of inflammatory cytokines and related proinflammatory and anti-inflammatory genes in the hippocampus. Recent data therefore indicate an association between epileptic seizures and the induction of inflammatory cytokines.

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