We read with great interest the article by Nakashima and coworkers,1 who described in detail the clinical and laboratory features of 5 patients with multiple sclerosis (MS) whose magnetic resonance imaging (MRI) films showed linearly shaped lesions along the intrapontine course of trigeminal fibers. All patients had various types of facial sensory disturbances, such as neuralgia, hypesthesia, and paresthesia, and the possible etiopathogenetic role of herpes simplex virus (HSV) infection was hypothesized.
Ferroli P, Farina L, Franzini A, Milanese C, Broggi G. Linear Pontine and Trigeminal Root Lesions and Trigeminal Neuralgia. Arch Neurol. 2001;58(8):1311-1312. doi: