We thank Dr Jellinger for reporting on his large and interesting series. We were pleased that data from the series of 176 autopsies in the Vienna Prospective Dementia Study confirm our observation that a significant percentage of demented subjects aged 80 years or older do not meet the pathological criteria for classic AD or DLB.1 Dr Jellinger appears to have defined DUE in a slightly different way than we did, and this difference may account for some of the modest differences between the 2 studies. Dr Jellinger identified 14 patients with cerebrovascular lesions and no or mild AD, 5 patients with hippocampal sclerosis with no or limited AD pathological conditions, and 42 other patients with DUE. Jellinger's DUE group had numerous plaques with little or no tangle pathologic characteristics or numerous tangles with little or no plaque pathologic characteristics. Virtually all of the 42 patients met the NIA-Reagan criteria for low likelihood of AD and had a CERAD score of 0 or A.
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