We thank Frisoni and Geroldi for their comments regarding the severity of cerebrovascular disease and motor dysfunction. In our study, we evaluated only infarcts with volumes less than 10 cm3. We did not quantify leukoaraiosis. The patients described by Frisoni and colleagues apparently had moderately extensive leukoaraiosis as well as lacunes, although the volume of the lacunes is not specified. Nevertheless, their subjects, similar to ours, did not differ in cognitive severity. We agree with their conclusion that concomitant subcortical cerebrovascular disease does not markedly modulate cognitive clinical features of AD.
Thal LJ. In reply. Arch Neurol. 2001;58(11):1939-1940. doi: