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Special Article
November 2001

Clinical and Pathological Diagnosis of Frontotemporal DementiaReport of the Work Group on Frontotemporal Dementia and Pick's Disease

Author Affiliations

From the Department of Neurology, Johns Hopkins University School of Medicine, and Zanvyl Krieger Mind/Brain Institute, Baltimore, Md (Dr McKhann); Departments of Pathology (Dr Trojanowski) and Neurology (Dr Grossman), University of Pennsylvania, Philadelphia; Department of Neurology, University of California at San Francisco (Dr Miller); Department of Pathology, Mayo Clinic Jacksonville, Jacksonville, Fla (Dr Dickson); and Departments of Psychiatry and Neurology, Harvard Medical School, Boston, Mass (Dr Albert).

Arch Neurol. 2001;58(11):1803-1809. doi:10.1001/archneur.58.11.1803

An international group of clinical and basic scientists participated in the Frontotemporal Dementia and Pick's Disease Criteria Conference at the National Institutes of Health in Bethesda, Md, on July 7, 2000, to reassess clinical and neuropathological criteria for the diagnosis of frontotemporal dementia (FTD). Previous criteria for FTD have primarily been designed for research purposes. The goal of this meeting was to propose guidelines that would enable clinicians (particularly neurologists, psychiatrists, and neuropsychologists) to recognize patients with FTD and, if appropriate, to expedite their referral to a diagnostic center. In addition, recommendations for the neuropathological criteria of FTD were reviewed, relative to classical neuropathology and modern molecular biology.