In a previous article, we used a statistical technique called cluster analysis to define 5 groups of elderly participants in the Cardiovascular Health Study (CHS)1 based on the pattern of findings on cranial magnetic resonance imaging (MRI). We labeled the clusters as follows: normal, atrophy, leukoaraiosis, simple infarct, and complex infarct. These clusters differed with respect to vascular risk factor profiles.
Longstreth, Jr WT, Diehr P, Beauchamp NJ, Manolio TA. Patterns on Cranial Magnetic Resonance Imaging in Elderly People and Vascular Disease Outcomes. Arch Neurol. 2001;58(12):2074. doi:10.1001/archneur.58.12.2074