Trebst and Ransohoff describe the emerging major roles that chemokines and their receptors have in the pathogenesis of demyelinating disease. Their review italicasizes a general model of leukocyte migration into the central nervous system under normal and inflammatory conditions that are mediated and modified by chemokines and their receptors. Future opportunities and challenges in this area of investigation are identified.
Petersen and colleagues, part of a collaborative international effort, have reviewed our current understanding of mild cognitive impairment and its role and position in the spectrum of disease of cognitive impairment and in normal aging. Mild cognitive impairment is an important concept and its role as a transitional disorder continues to be defined as it emerges more clearly and quantitatively.
This Month in The Archives of Neurology. Arch Neurol. 2001;58(12):1968-1969. doi:10.1001/archneur.58.12.1968