History of Neurology: Seminal Citation
January 2002

The Thalamus and Seizures

Author Affiliations

From the Departments of Neurology and Neurobiology, Yale University School of Medicine, New Haven, Conn.




Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

Arch Neurol. 2002;59(1):135-137. doi:10.1001/archneur.59.1.135

It seems natural that the thalamus, with its strong reciprocal connections to all areas of the cortex and its inherent tendency to fire rhythmic bursts of action potentials, would form an important part of networks underlying epileptic seizures. A dialogue on the relative importance of the thalamus and cortex in the pathogenesis of seizures, which began in the 1800s with John Hughlings Jackson, has included such luminaries as Penfield, Lennox, and Jasper, and it continues today.

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