IN THIS ISSUE OF THE ARCHIVES, Vrancken and colleagues1 from the University Medical Center in Utrecht, the Netherlands, further define the clinical characteristics of chronic idiopathic axonal polyneuropathy (CIAP). These unclassified sensory-predominant polyneuropathies are common in middle to late adulthood and have been an ongoing interest of the Utrecht group2 as well as of others.3 The age of onset for CIAP tends to be in the sixth decade of life or later. A large majority of patients with CIAP present with foot discomfort. Symptoms and signs are length dependent and progress slowly, and electrophysiologic and histologic data are consistent with a primarily axonal injury. Once identifiable causes for polyneuropathy have been excluded, patient management usually focuses on the treatment of neuropathic pain.
Wolfe GI. Chronic Idiopathic Axonal Polyneuropathy and Successful Aging of the Peripheral Nervous System. Arch Neurol. 2002;59(4):520-522. doi:10.1001/archneur.59.4.520