DURING THE past century, scientists have uncovered new knowledge in molecular genetics and generated novel tools for manipulating the molecules of the cell. Recent molecular strategies have shown promise in animal models. However, there are shortcomings in our current experimental systems and methods, resulting in failed experimental strategies. The goal of this article is to discuss current modes of treatment, recent molecular strategies that have shown promise in preclinical models, shortcomings in our current experimental systems and methods, and why our experimental strategies have failed to translate to beneficial treatments for patients suffering from brain tumors.
Fathallah-Shaykh HM. Darts in the Dark Cure Animal, but Not Human, Brain Tumors. Arch Neurol. 2002;59(5):721-724. doi:10.1001/archneur.59.5.721