In the study by Hoffmann et al,1CNTF genotypes in 349 patients with MS and 434 healthy controls were examined. This study confirms some of our results. The authors also detected no differences between allelic frequencies in patients with MS and controls, indicating that the CNTF null mutation is not a risk factor for the development of MS. As mentioned in their letter, the authors apparently could not find any association between the CNTF genotype and the MS course or disease severity.
Mäurer M, Linker R, Gold R, Toyka KV, Sendtner M, Rieckmann P. In reply. Arch Neurol. 2002;59(12):1974-1975. doi: