The comprehensive and intriguing report of 2 rare cases of sudden amnesia occurring as a result of some unrecognized pathophysiological process1 may offer further tantalizing evidence that a smoldering viral encephalitis with a predilection for mesial temporal lobes, perhaps reflecting synergistic interaction between influenza virus and herpes simplex virus type 1, could eventuate in Alzheimer disease.
Ball MJ. Unexplained Sudden Amnesia, Postencephalitic Parkinson Disease, Subacute Sclerosing Panencephalitis, and Alzheimer Disease: Does Viral Synergy Produce Neurofibrillary Tangles?. Arch Neurol. 2003;60(4):641-642. doi:10.1001/archneur.60.4.641