THE NASCET1 and the ACAS2 were the largest and best-organized trials affecting the management of extracranial carotid arteriosclerosis. Both trials have clearly defined patient populations that benefit from carotid endarterectomy compared with best medical management.
Moore WS. Resolved: NASCET and ACAS Need Not Be RepeatedThe Affirmative Position. Arch Neurol. 2003;60(5):775-778. doi:10.1001/archneur.60.5.775