Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS).1 Not only does fatigue affect up to 87% of patients with MS but as many as 40% of patients with MS regard fatigue to be their most disabling symptom.2 Although several therapies have shown some promise in the treatment of fatigue in patients with MS, the lack of a truly effective treatment for this symptom may be due to the underlying pathophysiology for MS fatigue still being debated.
Racke MK, Hawker K, Frohman EM. Fatigue in Multiple SclerosisIs the Picture Getting Simpler or More Complex?. Arch Neurol. 2004;61(2):176-177. doi:10.1001/archneur.61.2.176