We read with interest the ARCHIVES article by Hedera et al.1 They state that no neurologic abnormalities have been described in patients with excessive zinc ingestion. We would like to draw their attention to a patient recently described by us who developed a myeloneuropathy after years of high-dose zinc gluconate therapy, which was self-administered to prevent colds.2 Following the discontinuation of zinc and oral copper administration, we noted biochemical, clinical, and electrophysiologic improvement.
Kumar N, Ahlskog JE. Myelopolyneuropathy Due to Copper Deficiency or Zinc Excess?. Arch Neurol. 2004;61(4):604-605. doi:10.1001/archneur.61.4.604-b