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April 2004

Migraine and Tourette Syndrome—Reply

Arch Neurol. 2004;61(4):607. doi:10.1001/archneur.61.4.607

In reply

Barbanti and Fabbrini draw attention to reported evidence linking the pathophysiological features of migraine with the extrapyramidal system and suggest that the high frequency of migraine in TS, reported by us, may be attributed to the aberrant basal ganglia–thalamocortical circuitry underlying TS. They previously proposed a role of the basal ganglia in migraine based on their observation that the substantia nigra and red nucleus are activated during migraine attack, as demonstrated with functional magnetic resonance imaging.1

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