[Skip to Content]
[Skip to Content Landing]
July 2004

Genes for Movement

Arch Neurol. 2004;61(7):1006. doi:10.1001/archneur.61.7.1006

In 1940, Mount and Reback1 described familial paroxysmal choreoathetosis in a report in the ARCHIVES, more than 60 years ago. Known also as paroxysmal dystonic choreoathetosis (PDC) (Mendelian Inheritance in Man No. 11880) and paroxysmal nonkinesigenic dyskinesia, it is a movement disorder in which episodes of dystonia, chorea, and athetosis begin in childhood through early adulthood; involve the extremities, trunk, and face; and may be associated with dysarthria and dysphagia. These episodes are of varying lengths—from minutes to an hour—and may recur several times a day. Paroxysmal movements may occur spontaneously while at rest or may be precipitated by alcohol or caffeine use, fatigue, hunger, or emotional stress.

First Page Preview View Large
First page PDF preview
First page PDF preview