We were gratified by the interest Woodruff and colleagues took in our report of a case of FTDP-17.1 The authors emphasized the unusual feature in our patient of an onset of behavioral disturbance prior to the development of parkinsonism, which may be associated with the H1/H2 genotype of the tau protein.2 Our patient developed apathy followed a year later by parkinsonism and cognitive decline. We agree that it is important to perform tau haplotyping in as many of these patients as possible to define relationships between detailed genotypic patterns and phenotype in this disease, and we would be pleased to collaborate in such an undertaking.
Girotti F. Haplotype-Phenotype Correlations in Kindreds With the N279K Mutation in the Tau Gene—Reply. Arch Neurol. 2004;61(8):1327. doi:10.1001/archneur.61.8.1327-b