[Skip to Content]
[Skip to Content Landing]
Citations 0
August 2004

Evolving Antiepileptic Drug Treatment in Juvenile Myoclonic Epilepsy

Arch Neurol. 2004;61(8):1328. doi:10.1001/archneur.61.8.1328-a

The article by Prasad et al1 is a timely endeavor to readdress antiepileptic drug (AED) treatment in juvenile myoclonic epilepsy (JME) with the current pharmacopoeia. Numerous studies have established that approximately 80% of patients with JME become seizure-free when treated with valproate.16 Clonazepam, even in small doses, has a potent antimyoclonic effect. Phenytoin is often ineffective or worsens seizures. Carbamazepine is contraindicated because it aggravates JME in 68% of patients; however, occasionally it may improve the control of generalized tonic-clonic seizures. Historically, phenobarbitone and primidone were the preferred drugs and are still used in Europe and developing countries.5,6

First Page Preview View Large
First page PDF preview
First page PDF preview