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Correspondence
September 2004

Allan-Herndon-Dudley Syndrome: Should the Locus for This Hereditary Spastic Paraplegia Be Designated SPG 22?—Reply

Arch Neurol. 2004;61(9):1471. doi:10.1001/archneur.61.9.1471

In reply

Allan-Herndon-Dudley syndrome, a rare X-linked disorder, is characterized as follows: neonatal hypotonia followed in infancy by an inability to lift the head (limber neck) and subsequently by markedly delayed motor milestones (many individuals do not walk), generalized decreased muscle bulk, contractures at large and small joints, spastic paraplegia, extrapyramidal signs (variable), mental retardation (usually severe), dysarthria, ataxia, abnormal facies (elongated face with normal head circumference, bitemporal narrowing, and large ears), scoliosis, and broad, shallow pectus excavatum.14

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