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February 2006

Impulse Control Disorders and Dopaminergic Drugs—Reply

Author Affiliations

Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Neurol. 2006;63(2):299. doi:10.1001/archneur.63.2.299-a

In reply

We appreciated the interest in our article1 by Dr Morgan and colleagues. We agree that any drug that increases cerebral dopaminergic neurotransmission may facilitate development of impulse control disorders. We specifically focused on pathological gambling, however, and were struck by the association with dopamine agonist therapy and most notably pramipexole. As we commented in our article, levodopa may have been a contributory factor, and that seems likely in those cases where agonists were adjunctively administered.

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