In their retrospective, cross-sectional, case-control study of patients with multiple risk factors for cerebrovascular disease, Maulaz et al1 found increased risk of brain ischemic stroke in the 4 weeks after aspirin discontinuation (odds ratio, 3.34; 95% confidence interval, 1.07-10.39). These findings are consistent with previous studies, which showed that aspirin withdrawal may pose risk to coronary patients.2 Moreover, similar risks are reported after the cessation of nonsteroidal anti-inflammatory drug (NSAID) therapy.3 Taken together, these data suggest that there may be some common mechanism responsible for these withdrawal-related cardiovascular and cerebrovascular events.
Pijak MR. Rebound Inflammation and the Risk of Ischemic Stroke After Discontinuation of Aspirin Therapy. Arch Neurol. 2006;63(2):300-301. doi:10.1001/archneur.63.2.300-b