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March 2006

Sudden Onset of Somnolence in Parkinson Disease

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Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Neurol. 2006;63(3):467. doi:10.1001/archneur.63.3.467-a

We read with interest the recent article by Avorn et al.1 Sudden onset of somnolence/sleep (SOS) is an important clinical problem in Parkinson disease (PD) and remains an area of significant controversy. This study identifies dopamine agonists as increasing the risk of SOS in a large sample of tertiary care PD patients. The findings of the study are interesting and confirm previous reports of a higher risk of SOS associated with dopamine agonist therapy relative to levodopa and other antiparkinsonian drugs.2,3

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